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Application of ultrasound as clean technology for extraction of specialized metabolites from stinging nettle (Urtica dioica L.)

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Application of ultrasound as clean technology for extraction of specialized metabolites from stinging nettle (Urtica dioica L.)

dc.contributor.author	Sic Zlabur, Jana
dc.contributor.author	Radman, Sanja
dc.contributor.author	Opacic, Nevena
dc.contributor.author	Rasic, Anamaria
dc.contributor.author	Dujmovic, Mia
dc.contributor.author	Brncic, Mladen
dc.contributor.author	Barba Orellana, Francisco José
dc.contributor.author	Castagnini, Juan Manuel
dc.contributor.author	Voca, Sandra
dc.date.accessioned	2022-06-14T13:23:16Z
dc.date.available	2022-06-14T13:23:16Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/83134
dc.description.abstract	Nettle is a highly valued medicinal plant that is still largely neglected, both in terms of nutrition and use for pharmacological purposes. Tinctures, i.e., alcoholic extracts, are becoming increasingly popular nettle products, mainly because they allow better availability of phytochemicals and their stability over a longer period of time. The production of alcoholic extracts is a chemically demanding process that is still usually carried out using conventional techniques, which have numerous drawbacks. The use of green technologies such as ultrasound-assisted extraction (UAE), which is characterized by high efficiency of phytochemical extraction, shorter treatment time, and a much lower environmental footprint, is a suitable and sustainable solution. Therefore, the aim of this study is to determine the influence of the extraction method, conventional and ultrasound (by varying two ultrasound equipment systems), time and ethanol concentration on the extraction of specialized metabolites from nettle powder. Ultrasonic extraction using a probe system significantly contributed to increase the ascorbic acid yield, polyphenolic compounds, and antioxidant capacity of nettle extracts compared to conventional extraction. In addition, when a probe system was used during UAE, significantly less time was required for isolation of individual specialized metabolites compared to ultrasonic extraction in the bath. Ethanol concentration (50 and 80% v/v) also proved to be an important factor in the efficiency of extraction of specialized metabolites, with 80% ethanol being more effective for the isolation of ascorbic acid and pigment compounds (chlorophyll and carotenoids), while 50% v/v for the extraction of polyphenolic compounds. It can be concluded that extraction with the ultrasonic probe system is much more efficient in obtaining higher yields of specialized metabolites from nettle powder in a shorter time (average process duration 5-10 min) both compared to UAE in the bath and classical extraction. However, optimization of the key factors of time, solvent type, and ultrasonic power is necessary to maintain the nutritional quality of the nettle extract in order to obtain a final product with a high specialized metabolites content, antioxidant capacity, and functional value. The future application of alcoholic nettle extracts is based on the fact that these products have significant potential as functional foods and pharmacological preparations for the treatment of a number of but also to strengthen the immune system, mainly due to the rich nutritional composition and high content of various specialized metabolites. The prepared extracts can be safely taken orally by diluting the tinctures with water immediately before ingestion.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Nutrition, 2022, vol. 9, num. 870923, p. 1-17
dc.source	Sic Zlabur, Jana Radman, Sanja Opacic, Nevena Rasic, Anamaria Dujmovic, Mia Brncic, Mladen Barba Orellana, Francisco José Castagnini, Juan Manuel Voca, Sandra 2022 Application of ultrasound as clean technology for extraction of specialized metabolites from stinging nettle (Urtica dioica L.) Frontiers In Nutrition 9 870923 1 17
dc.subject	Plantes medicinals
dc.subject	Farmacologia
dc.title	Application of ultrasound as clean technology for extraction of specialized metabolites from stinging nettle (Urtica dioica L.)
dc.type	journal article	es_ES
dc.date.updated	2022-06-14T13:23:17Z
dc.identifier.doi	https://doi.org/10.3389/fnut.2022.870923
dc.identifier.idgrec	154168
dc.rights.accessRights	open access	es_ES