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Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping

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Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping

dc.contributor.author	Rodrigo Bort, Miguel
dc.contributor.author	Waddell, Kian
dc.contributor.author	Magee, Sarah
dc.contributor.author	Rogers, A. J.
dc.contributor.author	Alhusseini, Mahmood I.
dc.contributor.author	Hernández-Romero, Ismael
dc.contributor.author	Costoya-Sánchez, Alejandro
dc.contributor.author	Liberos, Alejandro
dc.contributor.author	Narayan, Sanjiv M.
dc.date.accessioned	2022-05-13T14:31:33Z
dc.date.available	2022-05-13T14:31:33Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/10550/82769
dc.description.abstract	Introduction: Regional differences in activation rates may contribute to the electrical substrates that maintain atrial fibrillation (AF), and estimating them non-invasively may help guide ablation or select anti-arrhythmic medications. We tested whether non-invasive assessment of regional AF rate accurately represents intracardiac recordings. Methods: In 47 patients with AF (27 persistent, age 63 ± 13 years) we performed 57-lead non-invasive Electrocardiographic Imaging (ECGI) in AF, simultaneously with 64-pole intracardiac signals of both atria. ECGI was reconstructed by Tikhonov regularization. We constructed personalized 3D AF rate distribution maps by Dominant Frequency (DF) analysis from intracardiac and non-invasive recordings. Results: Raw intracardiac and non-invasive DF differed substantially, by 0.54 Hz [0.13 - 1.37] across bi-atrial regions (R2 = 0.11). Filtering by high spectral organization reduced this difference to 0.10 Hz (cycle length difference of 1 - 11 ms) [0.03 - 0.42] for patient-level comparisons (R2 = 0.62), and 0.19 Hz [0.03 - 0.59] and 0.20 Hz [0.04 - 0.61] for median and highest DF, respectively. Non-invasive and highest DF predicted acute ablation success (p = 0.04). Conclusion: Non-invasive estimation of atrial activation rates is feasible and, when filtered by high spectral organization, provide a moderate estimate of intracardiac recording rates in AF. Non-invasive technology could be an effective tool to identify patients who may respond to AF ablation for personalized therapy.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Physiology, 2021, vol. 11, num. 611266
dc.source	Rodrigo Bort, Miguel Waddell, Kian Magee, Sarah Rogers, A. J. Alhusseini, Mahmood I. Hernández-Romero, Ismael Costoya-Sánchez, Alejandro Liberos, Alejandro Narayan, Sanjiv M. 2021 Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping Frontiers In Physiology 11 611266
dc.subject	Imatges tridimensionals en medicina
dc.subject	Enginyeria biomèdica
dc.title	Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping
dc.type	journal article	es_ES
dc.date.updated	2022-05-13T14:31:33Z
dc.identifier.doi	https://doi.org/10.3389/fphys.2020.611266
dc.identifier.idgrec	152895
dc.rights.accessRights	open access	es_ES