Histone post-translational modifications as potential therapeutic targets for pain management
NAGIOS: RODERIC FUNCIONANDO

Histone post-translational modifications as potential therapeutic targets for pain management

DSpace Repository

Histone post-translational modifications as potential therapeutic targets for pain management

Show full item record

View       (2.402Mb)

Exportar a Refworks
    
Torres-Perez, Jose V.; Irfan, Jahanzaib; Febrianto, Muhammad Rizki; Di Giovanni, Simone; Nagy, Istvan
This document is a artículoDate2021
Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription in nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translational implications of preclinical models and discuss opportunities and challenges of targeting histone PTMs to relieve pain in clinically relevant tissue injuries.

    Torres-Perez, Jose V. Irfan, Jahanzaib Febrianto, Muhammad Rizki Di Giovanni, Simone Nagy, Istvan 2021 Histone post-translational modifications as potential therapeutic targets for pain management Trends in Pharmacological Sciences 42 11 897 911
https://doi.org/10.1016/j.tips.2021.08.002

This item appears in the following Collection(s)

Show full item record

Search DSpace

Advanced Search

Browse

Statistics