In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review

Roderic Mòbil

Home non-mobile view

In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review

Mostra el registre parcial de l'element

dc.contributor.author Frangiamone, Massimo
dc.contributor.author Cimbalo, Alessandra
dc.contributor.author Alonso-Garrido, Manuel
dc.contributor.author Vila Donat, Pilar
dc.contributor.author Manyes Font, Lara
dc.date.accessioned 2022-01-14T14:36:38Z
dc.date.available 2022-01-14T14:36:38Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/10550/81329
dc.description.abstract Due to the globalization, mycotoxins have been considered a major risk to human health being the main con- taminants of foodstuffs. Among them, AFB1 and OTA are the most toxic and studied. Therefore, the goal of this review is to deepen the knowledge about the toxicological effects that AFB1 and OTA can induce on human health by using flow cytometry and immunofluorescence techniques in vitro and in vivo models. The examination of the selected reports shows that the majority of them are focused on immunotoxicity while the rest are con- cerned about nephrotoxicity, hepatotoxicity, gastrointestinal toxicity, neurotoxicity, embryotoxicity, reproduc- tive system, breast, esophageal and lung toxicity. In relation to immunofluorescence analysis, biological processes related to AFB1- and OTA-toxicity were evaluated such as inflammation, neuronal differentiation, DNA damage, oxidative stress and cell death. In flow cytometry analysis, a wide range of assays have been performed across the reviewed studies being apoptosis assay, cell cycle analysis and intracellular ROS measurement the most employed. Although, the toxic effects of AFB1 and OTA have been reported, further research is needed to clarify AFB1 and OTA-mechanism of action on human health.
dc.language.iso eng
dc.relation.ispartof Food and Chemical Toxicology, 2022, vol. 160, p. 112798
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Frangiamone, Massimo Cimbalo, Alessandra Alonso-Garrido, Manuel Vila Donat, Pilar Manyes Font, Lara 2022 In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review Food and Chemical Toxicology 160 112798
dc.subject Salut pública
dc.subject Salut
dc.subject Aliments Contaminació
dc.subject Aliments Toxicologia
dc.title In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-01-14T14:36:38Z
dc.identifier.doi https://doi.org/10.1016/j.fct.2021.112798
dc.identifier.idgrec 149675


Fitxers en aquest element

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Veure lloc complet

Roderic Mòbil