Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota

Roderic Mòbil

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Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota

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dc.contributor.author Rubio-Del-Campo, Antonio
dc.contributor.author Alcántara, Cristina
dc.contributor.author Collado, María Carmen
dc.contributor.author Rodríguez Díaz, Jesús
dc.contributor.author Yebra Yebra, María Jesús
dc.date.accessioned 2021-10-13T13:31:31Z
dc.date.available 2021-10-13T13:31:31Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/80457
dc.description.abstract Human milk oligosaccharides (HMOs) are a mixture of structurally diverse carbohydrates that contribute to shape a healthy gut microbiota composition. The great diversity of the HMOs structures does not allow the attribution of specific prebiotic characteristics to single milk oligosaccharides. We analyze here the utilization of four disaccharides, lacto-N-biose (LNB), galacto-N-biose (GNB), fucosyl-alpha 1,3-GlcNAc (3FN) and fucosyl-alpha 1,6-GlcNAc (6FN), that form part of HMOs and glycoprotein structures, by the infant fecal microbiota. LNB significantly increased the total levels of bifidobacteria and the species Bifidobacterium breve and Bifidobacterium bifidum. The Lactobacillus genus levels were increased by 3FN fermentation and B. breve by GNB and 3FN. There was a significant reduction of Blautia coccoides group with LNB and 3FN. In addition, 6FN significantly reduced the levels of Enterobacteriaceae family members. Significantly higher concentrations of lactate, formate and acetate were produced in cultures containing either LNB or GNB in comparison with control cultures. Additionally, after fermentation of the oligosaccharides by the fecal microbiota, several Bifidobacterium strains were isolated and identified. The results presented here indicated that each, LNB, GNB and 3FN disaccharide, might have a specific beneficial effect in the infant gut microbiota and they are potential prebiotics for application in infant foods.
dc.language.iso eng
dc.relation.ispartof Scientific Reports, 2020, vol. 10, num. 11845, p. 1-12
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Rubio-Del-Campo, Antonio Alcántara, Cristina Collado, María Carmen Rodríguez Díaz, Jesús Yebra Yebra, María Jesús 2020 Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota Scientific Reports 10 11845 1 12
dc.subject Microbiologia
dc.subject Lactobacils
dc.title Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-10-13T13:31:32Z
dc.identifier.doi https://doi.org/10.1038/s41598-020-68718-4
dc.identifier.idgrec 148217


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Roderic Mòbil