NAGIOS: RODERIC FUNCIONANDO
P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma
DSpace Repository
- DSpace Home
- Investigació
- Revistes
- Medicina oral, patología oral y cirugía bucal. Ed inglesa
- Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2012. Vol. 17, no. 5
- View Item
P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma
| dc.contributor.author | Leyva Huerta, Elba Rosa | es |
| dc.contributor.author | Ledesma Montes, Constantino | es |
| dc.contributor.author | Rojo Botello, Rebeca Estela | es |
| dc.contributor.author | Vega Memije, María Elisa | es |
| dc.date.accessioned | 2017-07-24T11:03:28Z | |
| dc.date.available | 2017-07-24T11:03:28Z | |
| dc.date.issued | 2012 | es |
| dc.identifier.uri | http://hdl.handle.net/10550/59881 | |
| dc.description.abstract | Objective : The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Study D esign : We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies. Results : We found p53 immunoexpression in 71.4 % OLP cases and 68.7 % OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy. Conclusions : Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease. | es |
| dc.source | Leyva Huerta, Elba Rosa ; Ledesma Montes, Constantino ; Rojo Botello, Rebeca Estela ; Vega Memije, María Elisa. P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 5 2012: 18- | es |
| dc.title | P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma | es |
| dc.type | journal article | es_ES |
| dc.subject.unesco | UNESCO::CIENCIAS MÉDICAS | es |
| dc.identifier.doi | 10.4317/medoral.18013 | es |
| dc.type.hasVersion | VoR | es_ES |
View
(1.047Mb)