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Analysis of the influence of parasympathetic postganglionic neurons on cardiac response in ventricular fibrillation

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Analysis of the influence of parasympathetic postganglionic neurons on cardiac response in ventricular fibrillation

dc.contributor.author	Guerrero Martínez, Juan Francisco
dc.contributor.author	Rosado Muñoz, Alfredo
dc.contributor.author	Serrano López, Antonio José
dc.contributor.author	Bataller Mompean, Manuel
dc.contributor.author	Chorro Gascó, Francisco Javier
dc.contributor.author	Such Miquel, Luis
dc.contributor.author	Alberola, A.
dc.date.accessioned	2015-04-15T07:16:23Z
dc.date.available	2015-04-15T07:16:23Z
dc.date.issued	2010	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/43038
dc.description.abstract	Physical training modifies the sympathetic-vagal balance of autonomic nervous system. Previous studies have shown that such training also produces intrinsic modifications of cardiac electrophysiological properties in isolated heart during Ventricular Fibrillation (VF). Ten NZW trained rabbits were studied to test if the modifications are related to the activity of postganglionic parasympathetic neurons. Two records per subject were acquired during VF: before (G1) and after (G2) the infusion of atropine to inhibit the activity of neurons. Mapping records were obtained using a 240-channel electrode array located in the left ventricle of isolated heart (perfused by Langendorff system). VF was induced by stimulation at increasing frequencies. To analyze the time course of fibrillation, the records were processed in 4-second consecutive segments. For each channel and segment, the following parameters were computed: 1) Dominant Frequency (DF), obtained by the Welch periodogram b) Normalized Energy (NE) in a frequency band centered at the DF; c) Regularity Index (RI), which analyzes the similarity of local activation waves in every segment and channel; d) Coefficients of Variance of DF (CVDF), NE (CVNE) and RI (CVRI). For each segment, we obtained the average value of each of the parameters analyzed for all electrodes. The results are: a) DF (G1: 13.671 ± 0.509 Hz, G2: 14.783 ± 0.455 Hz), b) NE (G1: 0.398 ± 0.014; G2: 0.380 ± 0.013); c) RI (G1: 0.855 ± 0.017; G2: 0.865 ± 0.015), d) CVDF (G1: 0.109 ± 0.009; G2: 0.098 ± 0.008), e) CVNE (G1: 0.398 ± 0.014; G2: 0.380 ± 0.013 ) f) CVRI (G1: 0.084 ± 0.009; G2: 0.078 ± 0.008). None of these parameters showed significant differences between groups. Thus, the parasympathetic postganglionic neurons seem to have no effect on the cardiac response in VF due to physical training.	es_ES
dc.language.iso	en	es_ES
dc.source	Guerrero Martínez, J. F.; et al. (2010). Analysis of the influence of parasympathetic postganglionic neurons on cardiac response in ventricular fibrillation. En: Computing in Cardiology.	es_ES
dc.title	Analysis of the influence of parasympathetic postganglionic neurons on cardiac response in ventricular fibrillation	es_ES
dc.type	conference output	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es_ES
dc.identifier.idgrec	067885	es_ES