Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model

Roderic Mòbil

Home non-mobile view

Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model

Mostra el registre parcial de l'element

dc.contributor.author López-García, Gabriel
dc.contributor.author Cilla Tatay, Antonio
dc.contributor.author Barberá Sáez, Reyes
dc.contributor.author Alegría Torán, Amparo Asunción
dc.contributor.author Recio, María C.
dc.date.accessioned 2020-03-25T13:25:33Z
dc.date.available 2020-03-25T13:25:33Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/73659
dc.description.abstract The potential anti-inflammatory effect of plant sterols (PS) enriched milk-based fruit beverages (PS, 1 g/100 mL) (MfB) with/without galactooligosaccharides (GOS, 2 g/100 mL) (MfB-G) in an experimental mice model of chronic ulcerative colitis was evaluated. Beverages were orally administered to mice every day by gavage to achieve PS and GOS doses of 35 and 90 mg/kg, respectively, and experimental colitis was induced by giving mice drinking water ad libitum containing 2% (w/v) dextran sulphate sodium (DSS) for 7 days, alternating with periods without DSS up to the end of the study (56 days). MfB beverage showed significant reduction of symptoms associated to ulcerative colitis and improved the colon shortening and mucosal colonic damage, but it was not able to reduce the increase of myeloperoxidase levels produced by DSS. MfB-G showed higher incidence of bloody feces and loss of stool consistency than MfB, as well as high levels of immune cells infiltration in colon tissue and myeloperoxidase. Therefore, PS-enriched milk-based fruit beverage could be an interesting healthy food to extend the remission periods of the diseases and the need to evaluate, in a pre-clinical model, the anti-inflammatory effect of the combination of bioactive compounds in the context of a whole food matrix.
dc.language.iso eng
dc.relation.ispartof Foods, 2019
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source López-García, Gabriel Cilla Tatay, Antonio Barberá Sáez, Reyes Alegría Torán, Amparo Asunción Recio, María C. 2019 Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model Foods
dc.subject Tracte gastrointestinal Malalties
dc.title Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-03-25T13:25:33Z
dc.identifier.doi https://doi.org/10.3990/foods8040114
dc.identifier.idgrec 135834


Fitxers en aquest element

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Veure lloc complet

Roderic Mòbil