The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

Roderic Mòbil

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The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

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dc.contributor.author Patiño-Galindo, Juan Ángel
dc.contributor.author Torres Puente, Manoli
dc.contributor.author Bracho Lapiedra, Maria Alma
dc.contributor.author Alastrué, Ignacio
dc.contributor.author Juan, Amparo
dc.contributor.author Navarro Ortega, David
dc.contributor.author Galindo, María José
dc.contributor.author Ocete Mochón, Dolores
dc.contributor.author Ortega González, Enrique
dc.contributor.author Gimeno Cardona, Concepción
dc.contributor.author Belda, Josefina
dc.contributor.author Domínguez, Victoria
dc.contributor.author Moreno Muñoz, Rosario
dc.contributor.author González Candelas, Fernando
dc.date.accessioned 2018-05-16T13:43:52Z
dc.date.available 2018-05-16T13:43:52Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/66202
dc.description.abstract HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups. The HIV epidemic in the CV is dominated by subtype B infections among local men who have sex with men (MSM). 270 transmission clusters were identified (>57% of the dataset), 12 of which included ≥10 patients; 11 of subtype B (9 affecting MSMs) and one (n = 21) of CRF14, affecting predominately intravenous drug users (IDUs). Dated phylogenies revealed these large clusters to have originated from the mid-80s to the early 00 s. Subtype B is more likely to form transmission clusters than non-B variants and MSMs to cluster than other risk groups. Multinomial analyses revealed an association between non-B variants, which are not established in the local population yet, and different foreign groups.
dc.language.iso eng
dc.relation.ispartof Scientific Reports, 2017, vol. 7, num. 11584, p. 1-10
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Patiño-Galindo, Juan Ángel Torres Puente, Manoli Bracho Lapiedra, Maria Alma Alastrué, Ignacio Juan, Amparo Navarro Ortega, David Galindo, María José Ocete Mochón, Dolores Ortega González, Enrique Gimeno Cardona, Concepción Belda, Josefina Domínguez, Victoria Moreno Muñoz, Rosario González Candelas, Fernando 2017 The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters Scientific Reports 7 11584 1 10
dc.subject Epidemiologia
dc.subject Malalties de transmissió sexual
dc.title The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-05-16T13:43:52Z
dc.identifier.doi https://doi.org/10.1038/s41598-017-10286-1
dc.identifier.idgrec 121300


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Roderic Mòbil